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KMID : 0923620190190050036
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Immune Network
2019 Volume.19 No. 5 p.36 ~ p.36
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Mesenchymal Stem Cells Ameliorate Renal Inflammation in Adriamycin-induced Nephropathy
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Kim Hyung-Sook
Lee Jae-Seob
Lee Hong-Kyung
Park Eun-Jae
Jeon Hye-Won
Kang Yu-Jeong
Lee Tae-Yong
Kim Kyung-Suk
Bae Sang-Cheol
Park Ji-Hyun
Han Sang-Bae
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Abstract
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Mesenchymal stem cells (MSCs) ameliorate the renal injury in Adriamycin (ADR)-induced nephropathy, but the mechanisms underlying their efficacy remain incompletely understood. In this study, we demonstrated that MSCs increased the survival, recovered body weight loss, and decreased proteinuria and serum creatinine levels in ADR-treated mice. MSCs also prevented podocyte damage and renal fibrosis by decreasing the expression of fibronectin, collagen 1α1, and α-smooth muscle actin. From a mechanistic perspective, MSCs inhibited renal inflammation by lowering the expression of CCL4, CCL7, CCL19, IFN-α/β, TGF-β, TNF-α, and chitinase 3-like 1. In summary, our data demonstrate that MSCs improve renal functions by inhibiting renal inflammation in ADR-induced nephropathy.
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KEYWORD
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Mesenchymal stem cells, Inflammation, Podocytes, Fibrosis
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